STEM CELLS AND THEIR PARACRINE FACTORS

The literature review is devoted to the analysis of paracrine factors stem cells various origins.
 Emphasis placed on fact that synthesis and secretions trophic characteristic not only cells, but also other body, such as liver, lungs, kidneys, both healthy pathologically changed, for all these factors, which are produced by different proposed genetic name cellular secretion, qualitativelyand quantitatively differs depending type producers factors.
 In parallel, concept “secretome“, widely used in literature, includes names conditioned environments. Humoral exosomes. broadest all-encom-passing term can be “secretome”, characterized composition activity understood those substances needed cell intercellular communication interaction with cells.
 effect secretome target production humoral significant trophic, stimulating properties, contain a large number growth cytokines, chemokines, determine their use pathology, described.
 specified features secretome, secreted depends many conditions, as: origin passages, conditions environment cultivation, duration action external hypoxia, temperature others.
 Unresolved questions were raised regarding receipt application. It believed including multidirectional mechanisms influence among following distinguished: proliferation inhibiting apoptosis, immunosuppressive immunostimulating, etc.